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KMID : 0613820070170081068
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Journal of Life Science
2007 Volume.17 No. 8 p.1068 ~ p.1074
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Distribution of Parvalbumin-Immunoreactive Retinal Ganglion Cells in the Greater Horseshoe Bat, Rhinolophus ferrumequinum
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Jeon Young-Ki
Kim Tae-Jin
Lee Eun-Shil
Joo Young-Rak
Jeon Chang-Jin
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Abstract
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Parvalbumin occurs in various types of cells in the retina. We previously reported parvalbumin distribution in the inner nuclear layer of bat retina. In the present study, we identified the parvalbumin- immunoreactive neurons in the ganglion cell layer of the retina of a bat, Rhinolophus ferrumequinum, and investigated the distribution pattern of the labeled neurons. Parvalbumin immunoreactivity was found in numerous cell bodies in the ganglion cell layer. Quantitative analysis showed that these cells had medium to large-sized somas. The soma diameter of the parvalbumin-immunoreactive cells in the ganglion cell layer ranged from 12.35 to 19.12 ㎛ (n=166). As the fibers in the nerve fiber layer were also stained, the majority of parvalbumin-immunoreactive cells in the ganglion cell layer should be medium to large-sized retinal ganglion cells. The mean nearest neighbor distance of the parvalbumin-immunoreactive cells in the ganglion cell layer of the bat retina ranged from 59.57 to 62.45 ㎛ and the average regularity index was 2.95 ± 0.3 (n=4). The present results demonstrate that parvalbumin is expressed in medium to large-sized retinal ganglion cells in bat retina, and they have a well-organized distributional pattern with regular mosaics. These results should be important as they are applicable to a better understanding of the unsolved issue of a bat vision. This data will help to provide fundamental knowledge for the better understanding of the unique behavioral aspects of bat flight maneuverability.
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KEYWORD
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Bat, distribution, immunocytochemistry, parvalbumin, retinal ganglion cell
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